●The Effect of Charge Mutations on the Stability and Aggregation of a Human Single  Chain Fv Fragment
James I. Austerberry et al.
European Journal of Pharmaceutics and Biopharmaceutics (2017) 115, 18-30
●Effect of PEG Molecular Weight and PEGylation Degree on the Physical Stability of  PEGylated Lysozyme
Josefine Morgenstern, Pascal Baumann, Carina Brunner, Jürgen Hubbuch
International Journal of Pharmaceutics (2017) 519(1-2), 408-417
●The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and its Stability
Xin Meng, Jack Clews, Vasileios Kargas, Xiaomeng Wang, Robert C. Ford
Cellular and Molecular Life Sciences (2017) 74, 23-38
●Proofreading of Substrate Structure by the Twin-Arginine Translocase is Highly Dependent on Substrate Conformational Flexibility but Surprisingly Tolerant of Surface  Charge and Hydrophobicity Changes
Alexander S. Jones et al.
BBA – Molecular Cell Research (2016) 1863(12), 3116-3124

●Prediction of Salt Effects on Protein Phase Behavior by HIC Retention and Thermal  Stability
Kai Baumgartner, Steffen Großhans, Juliane Schütz, Susanna Suhm, Jürgen Hubbuch
Journal of Pharmaceutical and Biomedical Analysis (2016) 128, 216-225
●The Effects of Irradiation on the Biological and Biomechanical Properties of an  Acellular Porcine Superflexor Tendon Graft for Cruciate Ligament Repair
Jennifer H Edwards et al.
Journal of Biomedical Materials Research (2016)
●Identification of Protein-Excipient Interaction Hotspots Using Computational  Approaches
Teresa S. Barata, Cheng Zhang, Paul A. Dalby, Steve Brocchini, Mire Zloh
International Journal of Molecular Sciences (2016) 17(6), 853
●Structure of USP7 Catalytic Domain and Three Ubl-domains Reveals a Connector  α-helix with Regulatory Role
Robbert Q. Kim, Willem J. van Dijk, Titia K. Sixma
Journal of Structural Biology (2016) 195, 11-18
●Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment
Nesrine Chakroun, David Hilton, Shahina S. Ahmad, Geoffrey W. Platt, Paul A. Dalby
Molecular Pharmaceutics (2016) 13, 307-319
●Hot Spots for the Solubility of Globular Proteins
Ashok Ganesan et. al.
Nat. Commun. (2016) 7, 10816 (doi:10.1038/ncomms10816)
●The Influence of Mixed Salts on the Capacity of HIC Adsorbers: A Predictive  Correlation to the Surface Tension and the Aggregation Temperature
Kai Baumgartner, Stefan A. Oelmeier, Jurgen Hübbuch
Biotechnology Progress (2016) 32(2), 346-354
●The Tribbles 2 (TRB2) Pseudokinase Binds to ATP and Autophosphorylates in a  Metal-Independent Manner
James I. Austerberry et al.
European Journal of Pharmaceutics and Biopharmaceutics (2017) 115, 18-30

●Examination of Thermal Unfolding and Aggregation Profiles of a Series of  Developable Therapeutic Monoclonal Antibodies
Mark L. Brader et al.
Molecular Pharmaceutics (2015) 12(4), 1005-1017
●The First Step of Peptide Selection in Antigen Presentation by MHC Class I  Molecules
Malgorzata A. Garstka et al.
PNAS (2015) 112(5), 1505-1510
●Developability Assessment During the Selection of Novel Therapeutic Antibodies
Alexander Jarasch, et al.
Journal of Pharmaceutical Sciences (2015) 104(6), 1185-1898
●Hoefavidin: A Dimeric Bacterial Avidin with a C-terminal Binding Tail
Orly Avraham, Amit Meir, Alexander Fish, Edward A. Bayer, Oded Livnah
Journal of Structural Biology (2015) 191, 139-148
●‘Dopamine-First’ Mechanism Enables the Rational Engineering of the Norcoclaurine  Synthase Aldehyde Activity Profile
Benjamin R. Lichman, et al.
FEBS Journal (2015) 282, 1137-1151
●Accelerated Formulation Development of Monoclonal Antibodies (mAbs) and  mAb-Based Modalities: Review of Methods and Tools
Vladimir I. Razinkov, Michael J. Treuheit, Gerald W. Becker
Journal of Biomolecular Screening (2015) 20(4), 468-483
●Arginine Dipeptides Affect Insulin Aggregation in a pH- and Ionic  Strength-Dependent Manner
Mariam M. Nuhu and Robin Curtis
Biotechnology Journal (2015) 10(3), 404-416
●Orthogonal Methods for Characterizing the Unfolding of Therapeutic Monoclonal
Antibodies: Differential Scanning Calorimetry, Isothermal Chemical Denaturation, and  Intrinsic Fluorescence with Concomitant Static Light Scattering
Deniz B. Temel, Pavel Landsman, Mark L. Brader
Methods in Enzymology (2015) 562, 355-385

●Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary  Membranous Nephropathy
Maryline Fresquet et al.
Journal of the American Society of Nephrology (2014) 26, 302-313
●The Effect of Arginine Glutamate on the Stability of Monoclonal Antibodies in  Solution
Priscilla Kheddo et al.
International Journal of Pharmaceutics (2014) 473(1-2), 126-133
●High Throughput Prediction of the Long-term Stability of Pharmaceutical  Macromolecules from Short-Term Multi-Instrument Spectroscopic Data
Nathaniel R. Maddux et al.
Journal of Pharmaceutical Sciences (2014) 103(3), 828-839
●Preformulation Study of Highly Purified Inactivated Polio Vaccine, Serotype 3
Wei Qi et al.
Journal of Pharmaceutical Sciences (2014) 103(1), 140-151
●A Low-Volume Screening Tool to Optimize Colloidal Stability for Highly  Concentrated Protein Formulations
Melanie Hofmann, Matthias Winzer, Christian Weber, Henning Gieseler
American Pharmaceutical Review (2014)
●Ensemble Refinement Shows Conformational Flexibility in Crystal Structures of  Human Complement Factor D
Federico Forneris, B. Tom Burnley, Piet Gros
Acta Crystallographica: Biological Crystallography (2014) D70, 733-743
●The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer that Inhibits  Geminin Function in DNA Replication Licensing
Christophe Caillat et al.
Journal of Biological Chemistry (2013) 288(44), 31624-31634
●The Physical Stability of the Recombinant Tuberculosis Fusion Antigens H1 and H56
Mette Hamborg et al.
Journal of Pharmaceutical Sciences (2013) 102(10), 3567-3578

●N-Terminal Truncation of an Isolated Human IgG1 CH2 Domain Significantly  Increases its Stability and Aggregation Resistance
Rui Gong et al.
Molecular Pharmaceutics (2013) 10, 2642-2654
●Impact of Short Range Hydrophobic Interactions and Long Range Electrostatic
Forces on the Aggregation Kinetics of a Monoclonal Antibody and a Dual-Variable  Domain Immunoglobulin at Low and High Concentrations
Vineet Kumar, Nitin Dixit, Liqiang (Lisa) Zhou, Wolfgang Fraunhofer
International Journal of Pharmaceutics (2011) 421(1), 82-93
●Automation and High-Throughput Technologies in Biopharmaceutical Drug Product  Development with QbD Approaches
Vladimir Razinkov, Jerry Becker, Cenk Undey, Erwin Freund, Feroz Jameel
Advances in the Pharmaceutical Sciences (2015) 18, 475-510
●Marine Natural Products for Protein Misfolding Modulation
James C. Griffin and Kathryn Vanya Ewart
Intech (2013), Using Old Solutions to New Problems - Natural Drug Discovery in the 21st  Century, Dr. Marianna Kulka (Ed.) DOI: 10.5772/54585
●High-Throughput Biophysical Approaches to Therapeutic Protein Development
Feng He, Vladimir I. Raxinkov, C. Russell Middaugh, Gerald W. Becker
Biophysics for Therapeutic Protein Development (2013) 4, 7-31
























地址: 北京市海淀区北四环中路229号海泰大厦7层719